High-fat diet and age alter microflora and cause inflammation in heart failure


Getting elderly and a high-fat diet enriched with omega 6 fatty acids are major contributors to health problems which range from diabetes to heart failure. How these factors govern the immune response is currently clarified — a calorie-dense, obesity-generating diet in aging mice interrupts the composition of their intestine microbiome. This interferes with creation of a system-wide nonresolving inflammation in acute heart failure, with a notable disruption of the immune cell profile, chiefly the neutrophil-leukocyte ratio.